Out of answers and running out of time, the agents must face the ghosts of their past in order to move forward.

The party’s over, and now the team must trust each other in order to face impending doom and an enemy that’s closer than they think.

No time for the team to play catch-up, there’s a planet to save.

Coulson’s life or death is the challenge the team finds themselves in, as the wrong decision will cause the destruction of Earth.

A newly determined Talbot takes Coulson to meet the enemy and attempts to avert Earth’s destruction.

The team finds themselves trapped and under siege at the Lighthouse.

While an agent’s life hangs in the balance, Fitz, Simmons and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

As Fitz and Simmons race to find a way to seal the Rift, they are faced with one of their greatest fears manifested.

Coulson and the team set out to rewrite the course of humanity’s fate; they’re unaware that their efforts will dramatically change one S.H.I.E.L.D. agent’s life.

Coulson and the team’s victory in the Framework is short-lived, revealing an even deadlier enemy looming against them all.

Daisy and Simmons race against the clock to get the team out of the Framework, but not everyone is ready to leave.

Daisy finds herself teamed up with an unlikely partner. Meanwhile, Aida prepares to put her ultimate end game into effect.

Aida continues to go crazy. And with 4 LMDs in the base cans Fitz and Jemma survive?

Supergirl investigates a mysterious symbol popping up all over National City, tracing its origins back to an ancient prophecy and the mark of the World Killer, Reign. Meanwhile, the tension…

Armek, a White Martian, descends on National City intent on taking M’gann back to Mars to face her punishment as a traitor. Hank and Supergirl determine the best way to…

Supergirl is forced to do battle with an unexpected foe and must risk everything – including her life – to prevent Non and Indigo from destroying every person on the…

J’onn J’onzz reveals the details of meeting Kara and Alex’s father, Dr. Jeremiah Danvers, and assuming Hank Henshaw’s identity. Also, Kara debates trusting someone new with her secret identity and…

Kara turns on her friends and the citizens of National City after being exposed to Red Kryptonite makes her malicious and dangerous. Also, Cat appears on THE TALK to discuss…

Kara travels to Superman’s Fortress of Solitude in hopes of learning how to defeat Indigo, a dangerous being who can transport via the Internet and who has a connection to…

Supergirl does battle with the deadly Master Jailer, who is hunting and executing escaped Fort Rozz prisoners. Also, Cat hires a second assistant, Siobhan Smythe, who immediately tries to one-up…

Kara’s friends must find a way to save her life when a parasitic alien attaches itself to her and traps her in a dream world where her family is alive…

With Astra in captivity at the DEO, her husband, Non, captures Hank, leading to a tense standoff between the two sides. Also, Kara continues to refute Cat’s allegations that she…

Personal and professional stress get the better of Kara when she goes too far during a training exercise against Red Tornado, a military cyborg commissioned by Lucy Lane’s father, General…

Kara’s two identities are stretched thin when Supergirl must protect National City from a series of bombings and Kara is tasked with babysitting Cat’s son, Carter. Also, James is conflicted…

Supergirl’s powers are tested when Reactron, one of Superman’s formidable enemies, arrives in National City and targets the young hero. Also, Cat plans to run an exposé on Supergirl.

After 12 years of keeping her powers a secret on Earth, Kara Zor-El, Superman’s cousin, decides to finally embrace her superhuman abilities and be the hero she was always meant…

Someone stumbles upon a brand new society unlike anything seen before.